Penetration of digoxin into cerebrospinal fluid.
نویسندگان
چکیده
The concentration of digoxin in the cerebrospinal fluid (CSF) of ten patients receiving conventional oral doses of this cardiac glycoside has been measured by a radioimmunoassay technique. Digoxin was undetected in eight patients and barely detectable in two, suggesting the presence of a significant blood-CSF barrier for digoxin. The implication of these findings is discussed.
منابع مشابه
Penetration of digoxin into cerebrospinal fluid G . D . SCHOTT
Introduction The importance of the cardiac glycosides in the treatment of a variety of heart diseases is firmly established and, although therapeutic problems remain, they are diminished by measurement of plasma levels of these drugs (Editorial, 1975). There has, however, been recent interest in the potential use of cardiac glycosides in neurological practice, including treatment of hydrocephal...
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ورودعنوان ژورنال:
- Postgraduate medical journal
دوره 52 613 شماره
صفحات -
تاریخ انتشار 1976